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2024 PROGRAM

We are proud to showcase the incredible work of so many local Bay Area scientists at our upcoming event. We hope you are all looking forward to the lineup of excellent speakers, including professors, students, post-docs, and industrial scientists as much as we are. 

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KEYNOTE SPEAKERS

Industry Short Talk Speakers

TECHNICAL PROGRAM
An ACS-Sponsored Event

8:00 am

9:00 am

 

9:40 am

10:00 am

10:20 am

10:40 am

11:20 am

 

11:40 am

 

 

12:00 pm

 

1:00 pm

1:40 pm

2:00 pm

2:20 pm

2:40 pm

3:00 pm

3:40 pm

4:00 pm

4:20 pm

5:00 pm

6:00 pm

Registration and Breakfast 

Professor Alanna Schepartz, UC Berkeley

Delivery, Delivery, Delivery

Hilary Beck, Eikon Therapeutics

The Power of the Purposeful Integration of Science and Engineering 

Kaipeng Hou, UC San Francisco

De Novo Design of Proteins for Efficient Stereoselective Catalysis

Coffee Break (20 min)

Chandru Venkataramani, Gilead

Discovery of Zamzetoclax (GS-9716), a Potent Orally Active MCL1 Inhibitor for the Treatment of Solid Tumors

Mariko Morimoto, Stanford

Tumor-Immune Cell Targeting Chimeras (TICTACs): Targeted Immune Reprogramming of the Tumor Microenvironment

Les Burnett, Revolution Medicines

Discovery of RMC-9805, an Oral, RAS(ON) G12D-Selective, Covalent, Tri-Complex Inhibitor

Lunch (1 hour)

Professor Noah Burns, Stanford

Primary and Secondary Metabolites as Inspiration for Synthesis

Mingshuo Zeng, Genentech

Discovery of Selective Tertiary Amide Inhibitors of CDK2

Jackson Baumgartner, UC Santa Cruz

Establishing Vanadium-Dependent Biocatalysts for Selective Small Molecule Halogenation

Wylie Palmer, Nurix

The Evolving Chemical Space of Beyond-Rule-of-Five (bRo5) Drugs
NX-5948 as a Case Study for CNS Penetrant Degrader

Coffee Break (20 min)

 

Lauren Holder, Novartis

Aminoisoquinolines as Fast-Acting Agents for IV Treatment of Severe Malaria

Jeremy Nicolai, UC Berkeley

Construction and Modification of Benzylic Difluorides

Anne Wampler, Stanford

Progress Towards (−)-Batrachotoxin and its Derivatives to Probe Voltage-Gated Sodium Channel Allostery

Professor Brian Shoichet, UC San Francisco

Following the Rabbit Into Chemical Space

Poster Session & Reception

Poster Awards

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  • Abhinav Chalasani, Aspiring Scholars Directed Research Program (Edward Njoo) - Mechanistic control over trifluormethyldiazomethane selectivity for 2+1 cyclopropanations versus photochemical 3+2 cycloaddition enables differential access to diverse trifluoromethylcyclopropanes and trifluoromethylpyrazolines

  • Ahit Kaan Tarhan, Stanford University (James Chen) - Design & synthesis of bicyclic guanidinyl inhibitors of ALDH1B1 targeting cancer stem cells

  • Alex Stephens, UC Davis (Cody Pitts) - Strain-release pentafluorosulfanylation, trifluoromethoxylation, and pentafluorosulfanoxylation of [1.1.0]Bicyclobutanes: Expanding Access to Fluorinated Cyclobutane Hybrid Bioisoteres

  • Andrew Chyu, Aspiring Scholars Directed Research Program (Edward Njoo) - Reactivity-informed Pharmacophore Editing and Biological Evaluation of Andrographolide and its A-ring Analogs

  • Carly Schissel, UC Berkeley (Alanna Schepartz) - Ribosomal Synthesis of Ketone-Containing Peptide Backbone via O to C Acyl Shift

  • Charis Amber, UC Berkeley (Richmond Sarpong) - Reductive Amination of Carbonyl C—C Bonds Enables Formal Nitrogen Insertion

  • Cheng-En (Andy) Hsieh, UC Davis (Jared Shaw) - Targeted Synthesis of Cycloartobiloxanthanone and Artoindonesianin Z-2 Using Donor/Donor Carbenes C–H Insertion

  • Christian Alexander Necoechea, University of San Francisco (Powers-Riggs) - Synthesis and Photophysics of Imidazole and Porphyrin-Based Non-Covalent Donor-Acceptor Dyads

  • Christine Albrecht, University of San Francisco (Herman Nikolayevskiy) - Development of a Selective DNA Alkylator with a Reverse-Prodrug Mechanism

  • Dane Holte, Gilead - Early Process Development of an LPAR1 Antagonist, GS-2278

  • Daynen Goss, Stanford University (Justin Du Bois) - Synthesis and biological characterization of N1-substituted saxitoxins

  • Edward Njoo,  (Edward Njoo) - with two posters below

  • Emily Hernandez, San Francisco State University (Eric Greene) - Towards a Conformational Dictionary: Cryo-EM Insights into Tau Fibrils

  • Eric Hantz, UC San Francisco (Adam Renslo) - A Systematic Study of (Hetero)aromatic Stacking at the Procaspase-6 Dimer Interface

  • Galen Liu, Aspiring Scholars Directed Research Program (Edward Njoo) - Reactivity-informed Pharmacophore Editing and Biological Evaluation of Andrographolide and its A-ring Analogs

  • Gilles Degotte, UC San Francisco (Adam Renslo) - Structure-based design of novel SARS-COV-2 MPro Inhibitor featuring an unusual warhead

  • Hanzhang Jin, UC Davis (Xi Chen) - Development of an efficient chemoenzymatic strategy for synthesizing amyloid-beta peptides (Aβs) and other glycopeptides

  • Haoqian Miao, UC Davis (Mark Mascal) - Recent Development of 5-(Chloromethyl)furfural-based Carbon Nucleophiles

  • Harahng Lee, Aspiring Scholars Directed Research Program (Edward Njoo) - Mechanistic control over trifluormethyldiazomethane selectivity for 2+1 cyclopropanations versus photochemical 3+2 cycloaddition enables differential access to diverse trifluoromethylcyclopropanes and trifluoromethylpyrazolines

  • Harshit Kolisetty, Affiliations with UC Berkeley, University of San Francisco, and Rockefeller University (Gregory Alushin) - Probing the Mechanosensitivity of Actin-Binding Proteins with Optical Tweezers

  • Hayden Anderson, Stanford University (Noah Burns) - Total Synthesis of GDGT Lipid Natural Products

  • Hengrui Chen, Aspiring Scholars Directed Research Program (Njoo Lab) - Mechanistic control over trifluormethyldiazomethane selectivity for 2+1 cyclopropanations versus photochemical 3+2 cycloaddition enables differential access to diverse trifluoromethylcyclopropanes and trifluoromethylpyrazolines

  • Isaac Joyner, UC Berkeley (John Hartwig) - Development of a De Novo Oxidase

  • Jack Liu, Stanford University (Elizabeth Sattely) - Taxol Biosynthesis: Missing Components and Unexpected Chemistry

  • James Vesto, UC Davis (Annaliese Franz) - Design of Organosilanol Ligands for Asymmetric N-H Insertion Catalysis

  • Jeffrey Zheng, UC San Francisco (Adam Renslo) - Development of Broad Spectrum ß-Lactamase Inhibitors

  • Jenna Manske, UC Berkeley (John Hartwig) - Chemoenzymatic Hydroaminomethylation for the Synthesis of Linear Primary Amines

  • Jennifer Le, Eikon - Chromatography as a Tool in High-throughput Physico-chemical and ADME-PK Property Estimation of Small Molecules

  • Jingxin Fu, UC Davis (Xi Chen) - Glycoprotein in vitro N-glycan engineering using carbohydrate active enzymes (CAZymes) expressed in Escherichia coli

  • Jose Manuel Ruiz, UC Davis (Jared T. Shaw) - Synthesis of Carbocycles by C-H Insertion of Donor/Donor Carbenes

  • Joshua Dunetz, Gilead - Enzymatic Resolution and Desymmetrization to Access Chiral Sulfonimidamides

  • Katharine Henn, UC Berkeley (Evan Miller) - A Reverse-Demand Sensor for Single-Neuron Voltage Imaging

  • Kevin Blanco-Herrero, UC Davis (Annaliese Franz) - Silanols – From Ligand Design in Enantioselective Catalysis to Blue Light Reactions

  • Kyan D'Angelo, UC Berkeley (John Hartwig) - Borylation of Alkyl C–H Bonds in Heterocycles

  • Lauren Ohman, UC Davis (Angelique Louie) - Utilization of antibody targeted perfluorocarbon nanoparticles for multiplexed 19F MRI of tumor-associated macrophages

  • Lee Schnaider, UC San Francisco (Bill DeGrado) - Proximity-enhanced ligation and protein design approaches for the stable and homogenous assembly of a 280 kilodalton 18-subunit nanopore complex for translational applications

  • Linda Ung, UC Davis (Jared Shaw) - Investigating the Influence of Remote Stereocenters on Donor/Donor C–H Insertions: Asymmetric Assembly of Cadinane Natural Products

  • Lucas Göttemann, UC Berkeley (Sarpong) - Development of a C–C Cleavage Cross-Coupling Macrocyclization Strategy – Total Synthesis of RAL Natural Products

  • Marziya Hasan,  - Biostable Shape Memory Polymer Foams

  • Matthew Epplin, Arcus - Discovery and Characterization of AB521, a Clinical-Stage, Potent, and Selective Hypoxia-Inducible Factor (HIF)-2α Inhibitor

  • Matthew Pompeo,  (Genentech) - Umpolung Flow Chemistry for the Synthesis of a Spirocyclic Building Block for SHP2 Inhibitor GDC-1971 (migoprotafib)

  • Nicholas Hadler, UC Berkeley (John Hartwig) - Predicting the Regioselectivity of Olefin Hydroformylation with Machine Learning

  • Nick Till, Stanford University (Carolyn Bertozzi) - Trogocytosis Targeting Chimeras (TrogoTACs) for Targeted Protein Transfer

  • Priya Jaishankar, UC San Francisco (Adam Renslo) - From Fragments to In Vivo Optimized Leads for the SARS-COV2 Macrodomain, an Emerging Target in Antiviral Therapy

  • Roger Diehl, University of Michigan (Alison Narayan) - CH-π Interactions are Required for Galectin-3 Function

  • Rushika Raval, Aspiring Scholars Directed Research Program (Edward Njoo) - Reactivity-informed Pharmacophore Editing and Biological Evaluation of Andrographolide and its A-ring Analogs

  • Ryan Steele, UC Berkeley (Sarpong, Richmond) - 1,2-Acyl Transposition through Skeletal Rearrangement of Dihydrobenzofurans

  • Seul Ki Yeon, UC San Francisco (Ian Seiple) - Hybrid antibiotics targeting the bacterial ribosome

  • Shang Ning, UC Berkeley (Tom Maimone) - Progress toward the total synthesis of aconicarmisulfonine A

  • Steven Miller, Stanford University (Justin Du Bois) - Design of Small Molecule Tools for the Study of CLC-2 Chloride Channels in the Central Nervous System

  • Tiffany Gu, Aspiring Scholars Directed Research Program (Edward Njoo) - Reactivity-informed Pharmacophore Editing and Biological Evaluation of Andrographolide and its A-ring Analogs

  • Xinyu Liu, Stanford University (Lynette Cegelski) - Broad-spectrum antibiotics against ESKAPE pathogens and mycobacteria through vancomycin conjugation

  • Yannick Kraemer, UC Davis (Cody Ross Pitts) - Tetrafluoro(aryl)sulfanylated Bicyclopentane Crystals that Self-Destruct upon Cooling

  • Yi-Cheng Kang, UC Berkeley (John Hartwig) - Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization

  • Yuanshin(Jack) Shiue, UC Davis (Jared Shaw) - Total Synthesis of Alopecurone C, Gnetoflavanol B, Rhamnoneuronal I and Their Derivatives featuring C–H Insertion Reactions with Donor/Donor Rhodium Carbenes

  • Yuanzhe Xie, UC Berkeley (John Hartwig) - Mechanistic Insights into Iridium-Catalyzed Hydroamination: Selective Migratory Insertion of Unactivated Terminal Alkenes into Ir–N Bonds

  • Zhijian Li, Stanford University (Paul A. Wender) - Organ and Cell Selective Delivery of RNA in vivo Using Guanidinylated Serinol Charge-altering Releasable Transporters

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